Analyzing Survival Data for Sequentially Randomized Designs

Bayesian Adaptive Methods for Clinical Trials of Targeted Agents

This chapter presents general Bayesian concepts and some specific designs for human clinical trials of targeted agents. The designs employ decision rules that use each patient’s protein or gene expression biomarkers, and possibly conventional prognostic variables, to choose an individualized treatment regime that may include one or several targeted agents. The Bayesian rules are sequentially ad...

Analyzing Group by Time Effects in Longitudinal Two-Group Randomized Trial Designs With Missing Data

Individual differences methods for randomized experiments.

Experiments allow researchers to randomly vary the key manipulation, the instruments of measurement, and the sequences of the measurements and manipulations across participants. To date, however, the advantages of randomized experiments to manipulate both the aspects of interest and the aspects that threaten internal validity have been primarily used to make inferences about the average causal ...

Asymptotic Properties of Doubly Adaptive Biased Coin Designs for Multitreatment Clinical Trials By

A general doubly adaptive biased coin design is proposed for the allocation of subjects to K treatments in a clinical trial. This design follows the same spirit as Efron’s biased coin design and applies to the cases where the desired allocation proportions are unknown, but estimated sequentially. Strong consistency, a law of the iterated logarithm and asymptotic normality of this design are obt...

Design and analysis of group-randomized trials: a review of recent methodological developments.

We review recent developments in the design and analysis of group-randomized trials (GRTs). Regarding design, we summarize developments in estimates of intraclass correlation, power analysis, matched designs, designs involving one group per condition, and designs in which individuals are randomized to receive treatments in groups. Regarding analysis, we summarize developments in marginal and co...